Get Rid of Heur:Trojan.Script.Generic from Infected Computer

Victim1: Hi! I just ran my anti-virus and it said that I have Heur.Trojan.Script.Generic, It did not give me the option to Quarantine, so I need to find out what to do about it. I'm running a laptop on Vista and it said that the critter is in C:\Documents and Settings\clotilde\AppData\Local\. Could you tell me what to do? Thank you!

Victim2: My normally dependable Dell,i5, Win 7, laptop suddenly began to be erratic, booting at odd times and showing strange, inappropriate error messages. A number of antivirus programs either can't load or can't run properly. I ran Kaspersky Security Scan and it reported the Heur:Trojan.Script.Generic, said "index (2) htm" was malware along with several entries it said were incorrect.

The Introduction of Heur:Trojan.Script.Generic

Heur:Trojan.Script.Generic has been detected as a stubborn Trojan by many anti-malware or anti-virus programs. In general, it can be distributed via free downloads, suspicious sites, other infections, or spam emails, and so on.